Eliza Dushku... Jessie Burlingame
Emmanuelle Chriqui... Carly
Jeremy Sisto... Scott
Lindy Booth... Francine
Kevin Zegers... Evan
Chris Flynn (Harrington) is on his way to a job interview and is driving through the mountains of West Virginia. Due to a chemical spill in the road ahead, he decides to take a different route, leading him through an abandoned dirt road in the middle of the woods. He then crashes into a car stranded in the center of the road.
The car he crashed into belongs to a group of friends on a hiking trip, which includes Jessie (Dushku). Their car's tire(s) were punctured by barbwire strung across the road. Two people stay with the cars, while the remainder of the group goes for help, only to find an old cabin isolated in the West Terre Haute woods. They discover that the cabin has many grisly horrors inside, such as entrails in a fridge and body parts in the bathtub. The cabin is home to a group of cannibalistic mountain men, who are horribly disfigured due to generations of inbreeding. The victims of these men are eaten once killed, such as Francine and others.
The group realize that the ones who own the cabin will not be friendly. A confrontation erupts with the disfigured men and the group make a mad dash through the woods only hoping to make it out alive. They spend a couple of days running from the mountain men, with two people from the group falling victim to the men. The remaining two people, Chris and Jessie, make it out of the woods alive and end up destroying the cannibals and their cabin. However at least one cannibal survives, as shown in the ending credits.